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April 1963

Fibrinolysis During and After Extracorporeal Circulation: Its Occurrence and Significance

Author Affiliations

Markle Scholar in Medical Science (Dr. Andersen).; From the Department of Surgery of the University of Buffalo School of Medicine and the E. J. Meyer Memorial Hospital.

Arch Surg. 1963;86(4):649-654. doi:10.1001/archsurg.1963.01310100133021

Although continued bleeding is no longer a major problem in the postoperative phase of patients undergoing extracorporeal circulation, blood loss is greater than that following other comparable thoracic surgical procedures and remains a matter of concern. Various aspects of control of blood coagulation after perfusion have received detailed attention without any single factor in the coagulation mechanism being identified as a principal cause of such difficulty.

Von Kaulla and Swan16,17 reported observing some degree of fibrinolysis postoperatively in patients undergoing total body perfusion, noting that this was seldom pronounced but in some cases might be fatal. These investigators believed the degree of activation was related to factors such as efficiency of perfusion and degree of postoperative acidosis. Others have also noted postoperative fibrinolysis,11,12 but relatively little specific information has been reported or evidence obtained indicating the precipitating mechanism. In an attempt to document further the incidence of abnormal

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