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June 1963

Pancreatic Secretion of Antibacterial Agents Through a New Pancreatic Fistula in the Dog

Author Affiliations

From the Department of Surgery, Presbyterian-St. Luke's Hospital, affiliated with the University of Illinois School of Medicine.

Arch Surg. 1963;86(6):1050-1061. doi:10.1001/archsurg.1963.01310120168024

There is no ideal way to collect total pancreatic secretion, uncontaminated, over an extended period of time. The ideal pancreatic fistula would be one through which the entire flow of pancreatic juice could be directed in its pure form with no alteration in the pancreas itself.

This study is concerned with the development of an improved method of collecting total pancreatic secretion and with evaluating the pancreatic secretion of certain antibacterial agents.

There have been no instances found in the available literature of the study of antibacterial agent secretion by the canine pancreas. The earliest recorded instance in the literature of human pancreatic secretion of an antibacterial agent was by Schnitker24 in 1943. Schnitker noted that after administration of sulfonamides they were present in the pancreatic juice. In 1944, Miller and Wiper15 reported that sulfanilamide was found in approximately the same concentration in the pancreatic juice as in