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July 1963

Effect of Serotonin Loading on Histamine Release and Blood Flow of Isolated Perfused Liver and Lung

Author Affiliations

From the Department of Surgery, University of Kentucky Medical Center.

Arch Surg. 1963;87(1):42-53. doi:10.1001/archsurg.1963.01310130044006

Considerable experimental and clinical evidence has been accumulated in recent years to indicate that a significant increase in the discharge of serotonin (5-hydroxytryptamine) into the vascular system occurs in both the postgastrectomy dumping and the metastatic carcinoid syndromes. The precise roles of the release of serotonin in the production of the physiologic changes and symptoms which occur in these syndromes is not entirely clear. The cardiac lesions which are found in the carcinoid syndrome are limited to the right side of the heart, and there is experimental evidence that serotonin is inactivated by the lung. Although experimental "dumping" is associated with a significant increase in serotonin in portal venous blood, a corresponding increase in systemic venous and arterial blood has not been demonstrated. In addition, there is evidence that serotonin is inactivated by the liver as well as the lung.

The purpose of this study is to evaluate, by means

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