The most disquieting feature common to all forms of effective cancer therapy is that they are injurious to the patient. The significance of this factor diminishes as the probability of cure increases with respect to a specific therapeutic method. A valid measurement of the balance between these two opposing factors continues to be particularly elusive in the field of cancer chemotherapy. A comprehensive search for agents with a relatively specific action against cancer during the last decade has met with limited success. Perhaps because of this fact, increasing interest has developed in techniques for improved utilization of agents with limited specificity of action and partial effectiveness against cancer. Most of these methods are designed to enhance tumoricidal effects while still controlling the level of host toxicity by establishing a differential in the dose of the drug between tumor and patient which favors the patient. Perfusion and infusion methods currently in
BENSON JW, KIEHN CL, HOLDEN WD. Cancer Chemotherapy by Arterial Infusion. Arch Surg. 1963;87(1):125–144. doi:10.1001/archsurg.1963.01310130127017
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