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September 1963

Experimental Venous Thrombosis and Thrombectomy

Author Affiliations

From the Nuffield Department of Surgery, The University of Oxford, and The Radcliffe Infirmary, Oxford, England.

Arch Surg. 1963;87(3):408-412. doi:10.1001/archsurg.1963.01310150044010

Venous thrombosis continues to represent a troublesome and even fatal complication of a variety of medical and surgical disorders. Numerous methods of treatment have been employed in both the prevention and the management of this condition, but it is generally agreed that much yet remains to be done in the satisfactory solution of this difficult problem.

In the recent past direct thrombectomy has been advocated for acute and chronic venous occlusion. This has been employed in the femoral and iliac vessels particularly, and encouraging results have been reported by several observers.1,2 In the present study an attempt has been made to devise a reliable method for the production of experimental thrombosis in large veins and to follow the natural history of such lesions with an investigation of the results following thrombectomy.

Methods  Twelve mongrel dogs (10-20 Kg.) were employed. Following premedication with morphine (1.25 mg. per kilogram) and chlorpromazine

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