Although adenocarcinoma of the vermiform appendix is a rare disease, it merits periodic consideration. In 1951 Hughes1 accepted only 19 of the cases which he studied from the literature as true primary lesions of the appendix. Earlier reports were misleading, inasmuch as carcinoids were often recorded as grade 1 adenocarcinomas. Collins2 discovered an incidence of 0.082% after studying 50,000 specimens, while McGregor3 reported an incidence of only 1 in 30,000. Brown and Husni4 reviewed the literature from 1900 to 1957 and found 52 cases. Since their report, the total was extended to 66 by Tarasidis,5 and more recently to 83 by Wilson's composite study from several hospitals in Vancouver, Canada.
This neoplasm in the early stages remains asymptomatic. However, as the condition progresses, it can manifest itself in a variety of ways. For instance, Niceberg7 reported a case presenting as an abdominal fistula associated
QURESHI MA, FOLEY WT, HAFNER CD. Adenocarcinoma of the Appendix: A Report of Four Cases. Arch Surg. 1963;87(3):453–456. doi:10.1001/archsurg.1963.01310150089020
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