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October 1963

Low-Flow Fail-Safe Intra-Arterial Infusion

Author Affiliations

From the departments of Surgery and Radiology, Stanford University.

Arch Surg. 1963;87(4):640-644. doi:10.1001/archsurg.1963.01310160102019

Since the original description by Duff, Sullivan, et al1 of intra-arterial infusion treatment of inoperable tumors of the head and neck, many methods and schedules of this type of therapy have been developed. These techniques have been applied largely to patients with inoperable head and neck tumors or with inoperable cancer in the pelvis. Recent work has produced several antitumor agents which are effective, at least temporarily, in controlling growth of tumors in man as well as in animals. Most of these agents have serious systemic toxicity, and great caution is required in their use to prevent undesired complications. The introduction of an antitumor agent into the arterial circulation of the tumor offers several distinct advantages, the greatest of which is the several-fold increase in concentration of the agent in the blood supplying the tumor as compared with the concentration in the general circulation. This relative concentration increase is