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October 1963

Severity of Renal Injury Incident to Abdominal Aortography: Effect of Concentration of Contrast Solution

Author Affiliations

Instructor in Surgery (Dr. Killen); Associate Professor of Surgery (Dr. Foster).; From the S. R. Light Laboratory for Surgical Research and the Department of Surgery, Vanderbilt University School of Medicine.

Arch Surg. 1963;87(4):650-652. doi:10.1001/archsurg.1963.01310160112022

Previous studies reported from this laboratory have revealed that a standardized injection of sodium acetrizoate 70% (Urokon) into the canine abdominal aorta results in renal damage.3,4 It seems necessary that a critical amount of contrast medium gain access to the renal parenchyma during aortography to produce renal injury severe enough to result in azotemia.3 This report concerns further definition of the nephrotoxic potential of abdominal aortography, especially as regards the concentration of the injected solution.

Method  Adult mongrel dogs served as test animals. A standardized abdominal aortic injection technique was used.4 The injections were made 1 cm below the origin of the left renal artery in the supine animal at laparotomy. Veterinary pentobarbital sodium (Nembutal) was used for anesthetization. The actual injection was accomplished by manual evacuation of the bolus of contrast medium from a syringe through a No. 18 gauge venipuncture needle. Four groups of animals