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October 1963

Oxidized Regenerated Cellulose for Hepatic Hemostasis

Arch Surg. 1963;87(4):669-672. doi:10.1001/archsurg.1963.01310160131026

Introduction  Oxidized regenerated cellulose is a relatively recent addition to the surgeon's armamentarium for hemostasis. Its hemostatic and absorbable qualities have been attested to by several authors in recent articles.1-5 There have also been several articles describing its chemical nature, the mechanism of solubility in human tissues, and, finally, the methods by which it stops bleeding.1,5 Briefly, it is a polyanhydroglucuronic acid manufactured from a substantially pure α-cellulose.5 Its specific hemostatic property apparently depends upon the formation of a coagulum consisting of cellulose acid and hemoglobin, and it has been demonstrated to be readily soluble in alkaline solution.5It is our purpose to evaluate this hemostatic gauze experimentally with regard to the frequently trying problem of hepatic hemostasis and to comment on a few of our clinical experiences with this material to date.

Methods and Procedures  Adult, medium-sized mongrel dogs were used. All operations were done

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