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November 1963

Histological Changes After Regional Chemotherapy: Brain and Face Tumors

Author Affiliations

From the Division of Neurosurgery, Duke University Medical Center.

Arch Surg. 1963;87(5):765-774. doi:10.1001/archsurg.1963.01310170051010

Introduction  When regional chemotherapeutic perfusions of neoplasms of the brain and face were begun, histological examination of specimens following perfusion was undertaken in order to evaluate the effect of the anticancer drug used. Sixty patients have undergone carotid perfusions, and half of these have had postperfusion histological sections on one or more occasions. This paper reports local histological changes following regional chemotherapy and the relationship between this histopathology and the therapeutic response.


Regional Perfusion Technique.  —The extracorporeal perfusion circuit consisted of a dual channel pump, a bubble oxygenator, a heat exchanger, a venous reservoir bottle, and a bubble trap, interconnected with plastic tubing.1 Donor blood was the perfusate for all internal carotid and some external carotid perfusions. Dextran was used in place of blood in some external carotid perfusions. One hundred per cent oxygen was used in the oxygenator, and the heat exchanger was maintained at 45 C