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November 1963

Antitoxic Effect of Aldosterone on Cats in Endotoxic Shock: Further Studies

Author Affiliations

From the Department of Surgery, Hahnemann Medical College.

Arch Surg. 1963;87(5):861-865. doi:10.1001/archsurg.1963.01310170147025

Within recent years, several investigators have utilized corticosteroids in the treatment of shock due to Gram-negative organisms. Bein and Jaques1 reported a lifesaving effect in cats when aldosterone was given intravenously in a single injection after an otherwise fatal injection of the endotoxin of Proteus.

Previous work2 in this laboratory showed that 46% of 46 cats survived when given a single intravenous injection of aldosterone (0.1 mg/kg), 30 minutes after receiving intravenously an otherwise fatal dose of the endotoxin of E scherichia coli. The purpose of the current investigation has been to further explore this antitoxic effect and if possible to extend its sphere of potential usefulness.

Methods  Healthy cats of either sex weighing 1.5-4.5 kg were used. A femoral cut down exposed the artery for recording blood pressure and the vein for intravenous injections. The cats were anesthetized with diallybarbituric acid (Dial)-urethane (1.1 ml/kg) intravenously. The temperature