Fracture of a long bone in the dog produces dramatic alterations in the hemodynamics of the injured region. Widespread vasodilation with accompanying increase in blood flow occurs in the fractured limb.4 Associated changes in the general circulation have not been clearly demonstrated.Textbooks of surgery and orthopedic surgery imply that extensive blood loss follows fracture of a long bone.1,2 On the other hand, we have been unable to find documented proof that significant hemorrhage accompanies the usual uncomplicated fracture. The present study was carried out in an effort to estimate, in a reasonably critical fashion, the amount of hemorrhage that accompanies a closed fracture of a long bone. Fracture sites were restricted to areas with relatively little paraskeletal soft tissue, in an effort to separate the effects of skeletal trauma from those of soft tissue injury. The dog rather than the human was employed in this investigation
ZEIDMAN H, WRAY JB, SCHNEIDER AJ. Alterations in Vascular Volume After Long Bone Fracture. Arch Surg. 1963;87(6):907–911. doi:10.1001/archsurg.1963.01310180023006
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