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December 1963

Systemic Effects of Massive Hepatic Necrosis: I. Acute Effects of Hepatic Infarction on the Kidneys

Author Affiliations

From the Departments of Experimental Surgery and Medicine A, Roswell Park Memorial Institute, New York State Department of Health.

Arch Surg. 1963;87(6):957-962. doi:10.1001/archsurg.1963.01310180073012

A relationship between liver disease or damage and kidney function has been observed and was termed the hepatorenal syndrome.1-3 The exact nature of this relationship has never been delineated and theoretically could involve insufficient liver function; circulatory insufficiency, such as dehydration and hypovolemia; massive outpouring of protoplasmic catabolites from disintegrating liver; or bacterial infection. Shock, alone or combined with any of the above, may be the precipitating factor.4,5

It is the purpose of the present study to examine whether severe hepatic damage, in the form of massive liver necrosis, is capable of suppressing renal performance completely or partially, in the absence of dehydration or shock. In another publication6 it was demonstrated that, in the same experimental model7 used for the present work, infection of the devitalized liver and hepatic insufficiency8 play no significant role.

Materials and Methods  Twelve apparently healthy mongrel dogs of either sex,