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January 1964

Low Molecular Weight Dextran in Small Artery SurgeryAntithrombogenic Effect

Arch Surg. 1964;88(1):78-82. doi:10.1001/archsurg.1964.01310190080009

In recent years extensive studies of the physiological properties of low molecular weight dextran (average molecular weight 40,000) have been conducted on both an experimental and a clinical level. These studies have centered predominantly around the use of dextran as a plasma substitute and its characteristic property of increasing the rate of blood flow through the smaller arteries, capillaries, and venules.

The purpose of this study was to determine the effect of low molecular weight dextran in preventing early thrombosis of small arteries subjected to operative trauma.

Two acute thrombus-producing procedures were carried out utilizing the carotid and femoral arteries of mongrel dogs (Fig 1). The vessels had an average diameter of 3.5 mm, and the animals ranged in weight from 10 to 12 kg. Anesthesia was achieved and maintained with intravenous veterinary pentobarbital sodium (Nembutal).

The first procedure consisted of a small transverse arteriotomy with removal of 2 cm

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