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March 1964

Effect of Fibrinolysis On Synthetic Vascular Prosthesis: Report of a Case and Experimental Study

Author Affiliations

Asst. Professor of Surgery, Okayama University Medical School (Dr. Inada); Assistant in Surgery, Okayama University Medical School (Drs. Shimizu, Morimoto, and Shigemoto).; From the Second Surgical Division, Okayama University Medical School.

Arch Surg. 1964;88(3):376-383. doi:10.1001/archsurg.1964.01310210050008

Advances in the field of vascular surgery are due mainly to developments in the use of vascular grafts. Preserved homografts have been discarded by many people because of the occurrence of late degeneration, causing rupture of the grafts. Synthetic prostheses, especially those made out of Dacron or Teflon, are now the choice for blood vessel substitutes. It has been nearly eight years since plastic prostheses were first used in vascular surgery, and various complications relating to its use, either early or late, have been reported in the literature.

Recently, we had an unpleasant experience with a Dacron graft. Severe, fatal bleeding occurred through the graft postoperatively and was believed due to the activated fibrinolysis. It is the purpose of this paper to report a grave complication relating to the use of synthetic vascular prostheses and to describe an analytical study of the effects of fibrinolysis upon plastic prosthesis.

Report of