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April 1964

Infusion of Pancreatic Enzymes into Biliary Radicals of Liver: Study of Influence Using Activated Enzymes

Arch Surg. 1964;88(4):589-595. doi:10.1001/archsurg.1964.01310220079013

Jaundice as seen in acute cholecystitis need not always result from common duct stone. As a matter of fact, a number of clinical studies indicate that jaundice occurs in over 30% of patients with acute cholecystitis, yet the incidence of common duct stone in these circumstances usually does not exceed 10% to 15%.1,2

During a three-year period, beginning July 1, 1960, through June 30, 1963, forty-four patients were operated upon for acute cholecystitis at the Milwaukee County General Hospital. Ten of the 44 patients proved to have associated common duct stones. The serum bilirubin had been determined preoperatively in 22 of the remaining 34 patients and was increased over the normal of 1.0 mg% in 17, or in half of those patients not harboring a common duct stone. This finding gives further support to the often expressed clinical impression that jaundice frequently occurs in patients with acute cholecystitis in