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May 1964

Renal Damage From Angiographic MediaThe Role of Vascular Obstruction

Arch Surg. 1964;88(5):812-818. doi:10.1001/archsurg.1964.01310230088019

Introduction  The intra-aortic administration of concentrated radiopaque agents is an established diagnostic technique. Complications are rare, but when they occur the kidney is most frequently involved.1 The mechanism of toxicity remains obscure. Considerable evidence has been presented2 to support a direct parenchymal effect. However, vasospasm, either arterial3 or venous,4 has been reported suggesting that renal damage is secondary to ischemia. The purpose of the present investigation was to determine the influence of various perfusates on the hemodynamic response of the canine kidney to angiographic media, since in previous experimental studies5 vascular obstruction arising from markedly hypertonic solutions including contrast agents was found to be related to the presence of the red cell.

Materials and Methods 

1. Renal Perfusion Studies.  —Adult mongrel dogs were anesthetized by the intravenous administration of pentobarbital sodium, 30 mg/kg body weight. A midline laparotomy was performed and the left kidney removed.