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July 1964

Thyroparathyroid Homotransplantation by Vascular Anastomosis: Effect of Immunosuppressive Drugs

Author Affiliations

From the Department of Surgery, Laboratory of Surgical Research, and the Department of Pathology, University of Pittsburgh School of Medicine.

Arch Surg. 1964;89(1):65-87. doi:10.1001/archsurg.1964.01320010067008

Ever since Schiff (1884)1 inserted homologous thyroid glands into the peritoneal cavity of dogs, several generations of laboratory investigators and surgeons have reported their findings following implantation of this gland. It has been placed as a free graft into the subcutaneous tissue and abdominal musculature of guinea pigs,2-4 the anterior chamber of the guinea pig,4 adult dog and rabbit eye,5 into different parts of the body of rabbits of various ages,6 rats,4,7-10 cats,11 and dogs,12,13 all under a variety of experimental conditions. In recent years implantation using the Millipore chamber technique has received attention.14-16 The human, subsequent to Kocher's first implantations (1908)17 in patients with thyroid deficiency, has also been a repeated recipient.18-23

Generated by clinical urgency, homografting of the parathyroid has perhaps received even more attention. In the laboratory the observations of Camus (1905)24 in the rabbit,