The most frequent reason for failure to cure most cancers is the vascular spread of the tumor. The two organs to which metastases most frequently occur are the liver and the lungs. Attempts to prevent the "take" of the tumor emboli in these organs or to discourage their growth once they have lodged in these organs have been made by Dr. Warren H. Cole and his associates, utilizing chemotherapeutic agents. They have demonstrated that certain chemotherapeutic agents, administered at the same time that tumor inocula are introduced into experimental animals, exert an influence in discouraging the "take" or growth of such neoplasms. At the clinical level such efforts have been discouraging. A nationwide study in which chemotherapeutic adjuvant theray was administered at the time curative resections were performed for cancers of the lung, stomach, rectum, and breast revealed no beneficial effects for the first three, but a possible beneficial
ARIEL IM. Radioactive Isotopes for Adjuvant Cancer TherapyAnimal Experimentation and Preliminary Results in Human Application. Arch Surg. 1964;89(2):244–249. doi:10.1001/archsurg.1964.01320020008002
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