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August 1964

Massively Bleeding Gastroduodenal Ulcers: Effects of Treatment on Morbidity and Mortality

Author Affiliations

From the departments of surgery of the Cook County Hospital, Northwestern University Medical School, and the Cook County Graduate School of Medicine.

Arch Surg. 1964;89(2):250-265. doi:10.1001/archsurg.1964.01320020014003

In a previous publication we reported certain general factors influencing the incidence, type, and outcome of patients bleeding massively from gastroduodenal ulcers.1 In that publication we defined massive hemorrhage as (1) hematologic evidence of loss of one-third normal blood volume; (2) clinical evidence of shock; or (3) the need for multiple transfusions to forestall or correct the two. In a second paper,2 the symptoms and signs of prognostic value in this same series of 2,008 patients with confirmed ulcers were reported. In a third publication dealing with this same group of patients3 the accumulated laboratory data was presented. In this report, the results of various measures employed between the years 1936 through 1955 inclusive are evaluated as to morbidity and mortality.

Evaluation of Treatment  The specific items selected for study in evaluating the treatment of this manifestation were:1. antacids2. medications3. vitamins4. diets5.

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