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August 1964

Changes in Gastric SecretionInduced by Urea Infusions and Nephrectomy

Arch Surg. 1964;89(2):273-274. doi:10.1001/archsurg.1964.01320020037006

In the course of metabolic studies in dogs following nephrectomy and ureteral ligation, it was noted that the chloride content of the excreta was often quite high. Since the excreta in this situation is almost entirely vomitus, we were attracted to a consideration of the components of gastric juice in uremia. The available data is sketchy in this regard. Peters1 noted that the gastric aspirate in patients with chronic uremia was low in both chloride and titratable acidity. Schreiner and Maher3 in an extensive review of the subject of the gastrointestinal symptoms of uremia do not refer to any studies of the acidity or electrolyte content of gastric juice under these circumstances. They take note of the high incidence of uremic gastritis, heart burn, vomiting, and gastric bleeding in uremia, and are inclined to favor the high concentration of ammonia which develops in the intestinal tract as the