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September 1964

Pancreatic Wounds Sealed With Plastic Adhesive: An Experimental Study in the Cat

Author Affiliations

From the Division of Basic Surgical Research, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC.

Arch Surg. 1964;89(3):546-553. doi:10.1001/archsurg.1964.01320030136024

Surgical procedures upon the pancreas are frequently associated with complications resulting from the leakage of pancreatic secretions into the peritoneal cavity. These complications include focal pancreatitis, peritoneal fat necrosis, adhesion formation, and fistula and pseudocyst formation. Conventional methods of treating pancreatic injury leave much to be desired. Even so confined a procedure as pancreatic biopsy in man is associated with appreciable morbidity and mortality.11

This study was undertaken to evaluate the efficacy of methyl-2-cyanoacrylate monomer,* a tissue adhesive, as a topical agent to prevent leakage of pancreatic secretions into the peritoneal cavity following a standardized pancreatic resection. The successful application of this material for this purpose would attest to its usefulness in pancreatic surgery.

Methods  Thirty-two male and female mongrel cats weighing 1.7 to 5.8 kg were used. The animals were separately caged, given Purina Cat Chow † and water, ad lib, pre- and postoperatively, and weighed weekly. The