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October 1964

Spontaneous Nocturnal Gastric Secretion—Acid, Pepsin: In Patients With or Without Duodenal Ulcer

Author Affiliations

Present address, Gastro-Intestinal Unit, Department of Internal Medicine, University Hospital, University of Utrecht (Dr. Sebus).

Arch Surg. 1964;89(4):709-715. doi:10.1001/archsurg.1964.01320040125022

The spontaneous nocturnal gastric secretion is raised in patients with a duodenal ulcer.1 A large output of acid during this period is presumably an important etiological factor for this disease. The peptic activity of the secretion, however, is rarely taken into consideration.

The determination of the concentration and total output of free acid as well as pepsin in the noctural gastric secretion from patients with or without duodenal ulceration forms the basis of this report.

Materials and Methods  The spontaneous gastric secretion of about 200 patients of both sexes, hospitalized for gastrointestinal complaints, was collected from 7 PM until 7 AM by continuous aspiration with a Wangensteen apparatus. The patients received a fluid diet for 24 hours and were fasted during the last three hours prior to the investigation. After measuring the volume of the secretion, the acidity was titrimetrically evaluated with dimethyl-yellow as indicator. The pepsin assay was

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