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November 1964

Blood Viscosity as a Determinant of Regional Blood FlowAn Experimental Study in Dogs Following Hemorrhage and After Infusion of Dextrans, Saline, Plasma, and the Shed Blood

Arch Surg. 1964;89(5):783-796. doi:10.1001/archsurg.1964.01320050029002

Introduction  Increasing importance of the role of blood viscosity alterations in various "flow problems," such as shock, hypothermia, extracorporeal circulation, thromboembolism, and peripheral vascular surgery is suggested by the growing popularity of this topic in current medical literature.1,4,9,10,14,18,21 Experimental and clinical studies have documented changes in cardiac output, myocardial contractility, and peripheral vasomotor tone in shock, whereas only recent attention has been given to changes occurring in the microcirculation, arbitrarily defined as that complex of arterioles, capillaries, and venules with internal diameters of less than 100μ.18 Interest in the subject of viscosity has been heightened through basic investigations by Swedish investigators of low viscous dextran (LVD) or low molecular weight dextran (LMDX) and its flow and viscosity altering properties.7,17This report concerns the effect of viscosity alterations on blood flow in an animal under conditions of experimental shock, documenting these changes with actual measurements of viscosity and