THE MEASUREMENT of hepatic circulation has presented multiple problems both in investigative and clinical application. Two approaches have been usually employed. One method has been to administer a substance which is selectively removed by the liver from the blood stream and then to estimate blood flow on the basis of its hepatic pickup or blood clearance. The other method has been to measure blood flow in the hepatic vessels per se. The first technique presumes functional integrity of the tissue in order to remove the blood borne indicator. The second approach necessitates the dissection and isolation of hepatic blood vessels (with or without cannulation). Another means to evaluate liver circulation without dependence on functional integrity or isolation of blood vessels would be to measure the clearance or "drainage" of material injected directly into the liver tissue. Kety1 has demonstrated that the clearance of a radioisotope from a tissue is
SIGEL B, QUE MY. Measurement of Local Hepatic Circulation: A Technique Using Tissue Clearance of Radioactive Sodium (22Na). Arch Surg. 1965;90(2):202–204. doi:10.1001/archsurg.1965.01320080026006
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