FUNCTIONING tumors of the pancreas which produce hypoglycemia continue to pose problems in diagnosis and management. The first successful removal of a functioning adenoma by Roscoe Graham in 192916 had been preceded by the work of Harris13 and Wilder35 which was instrumental in the discovery of this interesting pathophysiologic relationship. Members including Judd,18 Engel,8 Nesselrode,25 and Cheley3 soon reported successful removal of adenomata before this association in 1934. At that same meeting, George Thomason30 reported a patient with symptoms of hyperinsulinism upon whom he had operated and an adenoma was not found. Removal of the tail and body of the pancreas, subsequently found not to contain an adenoma, resulted in improvement for the short three month follow-up. Graham and Hartmann12 had reported a similar result in a 12-month-old child with hyperinsulinism after a 90% resection of the distal pancreas. These and
MILLER DR. Functioning Adenomas of Pancreas With Hyperinsulinism: Report of 13 Patients. Arch Surg. 1965;90(4):509–520. doi:10.1001/archsurg.1965.01320100053010
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