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April 1965

Renal HypothermiaIn Vivo Transaortic Perfusion With Ringer's Lactate Solution

Author Affiliations

CHICAGO
From the Department of Surgery, Presbyterian-St. Luke's Hospital. Hugh Robertson Exchange Fellow, 1963-1964, from London Hospital (Dr. Eadie). Present address: Department of Surgery, Chicago Medical School (Dr. Najafi).

Arch Surg. 1965;90(4):554-562. doi:10.1001/archsurg.1965.01320100098015
Abstract

Introduction  IT IS well established that hypothermia protects the kidney and hastens its recovery after a period of prolonged renal ischemia. Conventional means by which this may be achieved, using ice slush or hollow containers of various kinds containing ice placed around the kidney, are cumbersome and not without dangers. Total body hypothermia is time consuming and not without risk at lower temperatures.Surgical advances now include reconstructive procedures upon the renal artery, the abdominal aorta, and the kidney itself. Each of these carries its own risk of injury to the renal parenchyma.We hope to show in these experiments that by a simple method of transarterial perfusion with cold Ringer's lactate solution, adequate hypothermia may be given to the kidney to protect the cells from two hours of total ischemia, and that this method itself does not lead to renal injury.

Materials and Methods  Adult mongrel dogs, weighing 14

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