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May 1965

Squamous Cell Carcinoma Of Oral Cavity: Intra-Arterial Infusion With Fluorouracil and Idoxuridine

Author Affiliations

From the Division of Clinical Oncology and Department of Surgery, University of Wisconsin Medical Center. Assistant Professor of Surgery and Clinical Oncology (Dr. Johnson); Instructor in Surgery (Dr. Kisken); Director, Division of Clinical Oncology and Professor of Surgery (Dr. Curreri).

Arch Surg. 1965;90(5):760-763. doi:10.1001/archsurg.1965.01320110096016

THE FIVE-year survival of all patients with squamous cell carcinomas of the oral cavity has been reported as less than 50%.1 Moreover, this survival rate drops precipitously with the advanced lesions more than 3 cm in length. This report is concerned with the intermediate results obtained in 28 consecutive cases of this neoplastic disease with treatment completed 12 to 32 months ago. It will also briefly review the recent use of idoxuridine in association with fluorouracil as an adjunct to radiation therapy.

Materials and Methods  Twenty-eight patients were accepted consecutively for intra-arterial infusion with fluorouracil and subsequent radiotherapy according to the following criteria: (1) biopsy proof of squamous cell carcinoma of the tongue, tonsil, buccal mucosa, alveolar ridge, floor of the mouth, and oropharynx, (2) advanced disease with poor prognosis for survival with conventional therapy, (3) no prior therapy by surgery or radiation, and (4) an adequate infusion demonstrated

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