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June 1965

Simple Method for Establishing Hemorrhagic Shock in Dogs

Author Affiliations

From the Surgical Research Department of The Akron City Hospital.

Arch Surg. 1965;90(6):893-894. doi:10.1001/archsurg.1965.01320120095008

EXPERIMENTAL preparations used to investigate hemorrhagic shock involve controlled hypotension1,2 or the reinfusion of whole blood containing anticoagulants. A shock model which involves controlled pressure or anticoagulants cannot be used to determine the efficacy of a therapeutic agent in experimental shock since the agents themselves have an effect upon arterial pressure or capillary perfusion.3-5 The ideal preparation for clinical study eliminates any agent which alters the animal's physiologic response to shock.

The purpose of this paper is to analyze a shock model devised by us to fulfill the criteria mentioned above.

Materials and Methods  In 25 splenectomized dogs anesthetized with thiopental sodium (30 mg/kg), the femoral artery and vein were cannulated for bleeding, infusions, pressure recording, and blood sampling. Hemorrhagic shock was induced with a rapid arterial hemorrhage of 40% of the calculated blood volume. Ten minutes later an additional 10% of the dog's blood volume was removed;

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