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September 1965

Abolition of 'Tryptic Enteritis' in the Shocked Dog: Creation of an Experimental Model for Study of Human Shock and Its Sequelae

Author Affiliations

From the McGill University Surgical Clinic of the Montreal General Hospital. Medical Research Council Scholar (Dr. Bounous).

Arch Surg. 1965;91(3):371-375. doi:10.1001/archsurg.1965.01320150001001

HEMORRHAGE and retransfusion represent the principal method by which experimental normovolemic shock is induced in the laboratory animal. When the preparation is lethal, the time interval between retransfusion and death is usually very short, ranging from 2 to 12 hours. To bring about this situation one has to maintain a dog in hypovolemia with a blood pressure at 35 to 40 mm/Hg for two to four hours.1 After retransfusion of blood the outcome is rather clear cut; the animal either dies or recovers completely. In the latter instance the animal awakens from anesthesia much like an animal subjected to a nonshocking surgical procedure of comparable duration: the rapid clinical recovery is reflected by the lack of significant metabolic or pathological alterations. From 100% survival after 60 to 90 minutes of hypovolemia, to 100% mortality after four hours of hypovolemia, the difference in duration of the hypovolemic phase and the

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