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September 1965

Wound-Stimulating Effect of Homologous and Heterologous Cartilage

Arch Surg. 1965;91(3):523-525. doi:10.1001/archsurg.1965.01320150153031

IT has been firmly established that bovine tracheal cartilage powder will speed the early healing of sutured, incised wounds and open, granulating wounds in normal rats, guinea pigs and mice.1-5 Additional studies from this laboratory have shown a more dramatic effect in the wounds of diabetic rats.6,7 To date, only heterologous cartilage powder has been investigated. Because McKhann8 found that animals whose immune mechanisms had been stimulated healed less rapidly than did normal animals, it seemed appropriate to test the effect of homologous cartilage on wound healing and to compare this effect with that brought on by heterologous material. For completeness, autologous material should also have been tested, but practical factors limited such an investigation.

Methods  Male albino Wistar rats weighing from 140 to 200 gm (.03 to.04 lb) were housed in individual cages and maintained on a standard laboratory diet. Under intraperitoneal pentobarbital anesthesia, the animals