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October 1965

Quantitation of Morphologic Changes in Canine Stomach After Gastric Freezing

Author Affiliations

From the Department of Surgery, University of Minnesota Hospitals.

Arch Surg. 1965;91(4):575-583. doi:10.1001/archsurg.1965.01320160029006

RECENT REPORTS including those of double-blind studies concerning the efficacy of gastric freezing as treatment of patients with medically refractory duodenal ulcers are conflicting. The reports of Rose1 and S. L. Wangensteen2 and their respective colleagues suggest that freezing produces relief from ulcer pain in most of such patients while the report of Perry and associates3 indicates that freezing produces relief from ulcer pain in few of such patients. S. L. Wangensteen2 states that gastric acid secretion is depressed for six months after freezing while the others1,3 state that no change in acid secretion occurs thereafter.

The reports of descriptive (qualitative) microscopical changes after gastric freezing are also conflicting. The report of Allcock and co-authors4 suggests that the numbers of chief and parietal cells are temporarily decreased after freezing while the reports of Owens,5 Nabseth,6 and Gilat7 and their respective co-workers