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December 1965

Physiologic Effects of Rapid Hemodilution

Author Affiliations

From the Halsted Laboratory for Experimental Surgery, University of Colorado School of Medicine.

Arch Surg. 1965;91(6):887-892. doi:10.1001/archsurg.1965.01320180021006

IN THE PAST two years the concept of hemodilution as a technique for perfusion during open-heart surgery has gained increasing attention. This technique although only recently used to any extent in clinical practice, was first suggested by the work of Gollan.1 Later Neptune2 devised a system of using saline as a priming fluid without involving significant hemodilution. Long3 reported on the use of low molecular weight dextran as a means of reducing "sludging" and Sakakibara,4 in Japan, used an aminoacid solution as a priming fluid. Greer and Zuhdi,5 DeWall,6 Cooley7 and Paton8 have all reported on the clinical use of systems in which the priming fluid was 5% dextrose in water in a volume varying between 16 to 20 cc/kg of the patient's weight. In these systems the priming volume is returned to the patient at the end of the operation and,