IN THE PAST two years the concept of hemodilution as a technique for perfusion during open-heart surgery has gained increasing attention. This technique although only recently used to any extent in clinical practice, was first suggested by the work of Gollan.1 Later Neptune2 devised a system of using saline as a priming fluid without involving significant hemodilution. Long3 reported on the use of low molecular weight dextran as a means of reducing "sludging" and Sakakibara,4 in Japan, used an aminoacid solution as a priming fluid. Greer and Zuhdi,5 DeWall,6 Cooley7 and Paton8 have all reported on the clinical use of systems in which the priming fluid was 5% dextrose in water in a volume varying between 16 to 20 cc/kg of the patient's weight. In these systems the priming volume is returned to the patient at the end of the operation and,
SAKAI Y, PATON BC. Physiologic Effects of Rapid Hemodilution. Arch Surg. 1965;91(6):887–892. doi:10.1001/archsurg.1965.01320180021006
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