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January 1966

High Levels of Blood Histamine And Peptic Ulcer: In Patient With Portacaval Shunt

Author Affiliations

From the departments of anesthesiology, pharmacology, and surgery, University of Florida College of Medicine.

Arch Surg. 1966;92(1):96-97. doi:10.1001/archsurg.1966.01320190098022

MANY.ANY OBSERVATIONS in man and animal suggest that histamine contributes to the gastric hypersecretion and peptic ulcer that may arise after portacaval shunt operation.1-3 However, blood histamine levels in humans with a portacaval shunt and peptic ulcer have not been reported. Therefore, we wish to report the occurrence of gastric hypersecretion, an intractable peptic ulcer, and a high blood histamine level in a patient who had undergone portacaval shunt surgery for portal hypertension.


Histamine.  —Blood histamine was determined by a modification (Anton and Sayre, in preparation) of the fluorometric procedure of Shore et al.4 Blood was drawn into a heparinized plastic syringe from an antecubital vein and immediately transferred to an iced, plastic centrifuge tube. An aliquot of whole blood was removed and then the specimen was centrifuged at 3,000 × G for 20 minutes to obtain plasma, buffy coat, and red cells. Patients were in the

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