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March 1966

Effects of Graded Hemorrhage on Renal Blood Flow in Unanesthetized Dogs

Author Affiliations

From the departments of surgery, Kansas University Medical Center, and the Veterans Administration Hospital, Kansas City, Mo.

Arch Surg. 1966;92(3):371-373. doi:10.1001/archsurg.1966.01320210051009

IT HAS been demonstrated that anesthesia has an important effect on renal physiology.1-7 With the increasing current interest in shock, the influence of this variable on renal blood flow in the hypovolemic animal should be reevaluated. It is the purpose of this report to describe the effect of graded hemorrhage on renal blood flow in both anesthetized and unanesthetized dogs.

Method  Six healthy mongrel dogs varying in weight from 14.5 to 23.5 kg (32 to 51.6 lb) were studied. Preliminary blood volumes were inferred following plasma volume determinations using either radio-iodinated serum albumin or Evans Blue Dye. The animals were anesthetized with sodium pentobarbital (25 mg/kg IV). Electromagnetic flowmeter probes * were implanted about the left renal artery after it had been exposed through an incision in the left flank. Extra efforts were made to minimize blood loss during the procedure. With the flowmeters in place and the connectors fixed

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