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March 1966

In Vitro Mobilization of Atherosclerotic Plaque Lipids: I. Incubation Procedures

Author Affiliations

From the Department of Surgery, Hahnemann Medical College, Philadelphia.

Arch Surg. 1966;92(3):407-413. doi:10.1001/archsurg.1966.01320210087019

THESE background experiments have been undertaken in order to determine whether it is possible to mobilize chemically any of the lipids present in atherosclerotic plaques with the ultimate objective of applying the principle of regional isolation perfusion, as developed by Creech for regional cancer therapy, to the patient with diffuse atherosclerosis of a limb or organ. With such an objective, this first step was undertaken to determine the amount of lipid which could be removed from the atherosclerotic vessel under conditions of in vitro incubation of the vessel with various lipid "solvents."

Background  The term atherosclerosis describes a specific disease process, one among the arterioscleroses; it is characterized by focal thickenings of the intima in which stainable lipids can readily be demonstrated in and between the cellular elements.1The earliest lesion is the fatty streak. By stripping the intima of an early lesion it is possible to remove the

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