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March 1966

In Vitro Mobilization of Atherosclerotic Plaque Lipids: II. Perfusion

Author Affiliations

From the Department of Surgery, Hahnemann Medical College, Philadelphia.

Arch Surg. 1966;92(3):414-417. doi:10.1001/archsurg.1966.01320210094020

THIS investigation has been undertaken in order to determine whether it is possible to mobilize the lipids present in an atherosclerotic plaque and thereby to remove some of them using a perfusion technique. A previous experiment has demonstrated that certain substances are capable of mobilizing fats when, in vitro, they are incubated with the arteries. The current study has been an extension of the study of the mobilization of the lipids in vitro by perfusion of the arteries. Ultimately, the aim of the study would include the application of the isolation perfusion technique developed by Creech and associates1 as in the treatment of cancer

The chemistry of the atherosclerotic vessel, having been reviewed in the previous paper, is not included here. The results obtained by Buck and Rossiter2 (Table 1, p 407, this issue) form the basis of comparison with the present results.

The perfusants selected were based