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May 1966

Hepatic Morphology and Function: Alterations Associated With Acute Pancreatitis

Author Affiliations

From the Department of Surgery, Northwestern Medical School. Chicago.

Arch Surg. 1966;92(5):664-671. doi:10.1001/archsurg.1966.01320230012003

NUMEROUS studies have demonstrated the frequent association of diseases of the liver, the extrahepatic biliary ducts, and the pancreas. This combination is not surprising in view of the intimate anatomical relationship of these organs. The biliary ducts and pancreatic ducts join to form a common terminal ampulla proximal to the duodenum in from 60% to 90% of specimens subjected to careful autopsy study.1,2 The celiac axis supplies arterial blood to both the liver and the pancreas, while venous drainage from the pancreas enters the liver through the portal system, and the thoracic duct provides a common pathway for lymphatic drainage from both organs.

Stenson and associates3 found inflammatory changes in the pancreas in 72 of 75 cirrhotic patients, and similar findings have been reported by Steigmann.4 Lindsay and associates5 produced fatty infiltration of the liver in dogs subjected to a high fat, low protein diet, and

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