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May 1966

Action of Antidiuretic Hormone on Gastric Secretion

Author Affiliations

From the departments of anatomy and surgery, School of Basic Medical Sciences and College of Medicine, University of Tennessee Medical Units, Memphis.

Arch Surg. 1966;92(5):699-703. doi:10.1001/archsurg.1966.01320230047008

THE FIRST animal experiments involving the action of posterior pituitary extracts on the stomach were reported in 1916. Rogers and co-workers observed that pituitary extracts reduced the flow of gastric secretion in Pavlov pouch dogs.1 Dodds found that single large subcutaneous injections of the posterior pituitary extract produced temporary collapse, bloody diarrhea, and decreased food intake in rabbits. If these animals were examined in the early stages of the reaction, acute gastritis was found, confined to the acid secreting portion of the mucosa.2,3 Repeated oral or subcutaneous administration of the posterior pituitary extracts was found to cause single punched-out ulcers in the acid-bearing area of the rabbit's stomach,4 blanching of the stomach and duodenum in rabbits,5 and multiple hemorrhages, erosions, and small ulcers in the dog's stomach.6 This gastrotoxic factor was found to be associated with the pressor and not the oxytocic fraction of the

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