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June 1966

Infusion Chemotherapy in Head and Neck Tumors

Author Affiliations

From the Charleston Foundation Laboratory of Cancer Research and Department of Surgery, West Virginia University Medical Center, Morgantown.

Arch Surg. 1966;92(6):951-957. doi:10.1001/archsurg.1966.01320240139031

THE PATIENTS with advanced cancers of the head and neck remain a difficult palliative problem for the oncologist. Their systemic metastases develop relatively late in spite of the locally extensive disease and often the adjacent tissues will tolerate no additional radiation therapy; and the tumor distribution is such that neurosurgical procedures have little or nothing to offer for pain relief. This study evaluates the role of intraarterial infusion chemotherapy in such advanced head and neck cancer patients in terms of pain relief, tumor regression, and operability after infusion therapy.

Materials and Methods  Eleven patients with advanced head and neck tumors were given 15 courses of intra-arterial infusion chemotherapy. Their ages ranged from 18 to 81 years, their mean age being 49 years. Nine of the patients were male, two were female. Nine patients had squamous cell carcinomas of the head and neck region, one patient had a malignant melanoma of

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