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August 1966

Effect of Variations in Antrum Acidity on Gastrin Release

Author Affiliations

From the Department of Surgery of the University of Florida College of Medicine, Gainesville.

Arch Surg. 1966;93(2):286-290. doi:10.1001/archsurg.1966.01330020078011

IN 1954 Woodward et al1 reported that irrigation of isolated vagus-innervated antrum pouches in dogs with liver solutions produced a vigorous secretion of gastric juice from a Heidenhain pouch when the perfusate was neutral or faintly alkaline in reaction but little or no secretion where the perfusate was acidified. In later experiments with the same types of preparation, Woodward and his associates2 found that the secretory response to distention of the isolated antrum was also regularly blocked when the antrum was perfused with N 10 HCl solutions. N 50 HCl with a pH of 1.7 was found to be ineffectual. Nitric and sulfuric acids were equally as effective as HCl indicating that the important factor was the hydrogen concentration. These early observations have been repeatedly confirmed and the later work has been very largely directed to the question: does acidification of the antrum cause the release of a

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