IN PERIPHERAL nerve injuries, the type of damage greatly influences both the rate of regeneration and the quality of return. Results are poorest in cases where the nerve is completely severed and the framework destroyed. If, however, the framework is preserved, as in a crushing injury, an excellent return of function is more possible even though damage is severe enough to cause Wallerian degeneration. After experimental crushing injury, the rate of regeneration is also more rapid and the functional recovery better than after division. In fact, Guttmann and his associates found that in the rabbit recovered motor function after crush was indistinguishable from the normal, whereas after suture it was always imperfect.1 This suggests that in crushing injuries something has been preserved which prevents "confusion" at the site of the lesion and permits rapid and complete maturation of regenerating fibers. Ramon Y Cajal correlates the rapid return of good
SMITH JW. Factors Influencing Nerve Repair: I. Blood Supply of Peripheral Nerves. Arch Surg. 1966;93(2):335–341. doi:10.1001/archsurg.1966.01330020127022
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.