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September 1966

Lung Allografts With Delayed Opposite Pulmonary Artery Ligation

Author Affiliations

From Bryn Mawr Hospital, Bryn Mawr.

Arch Surg. 1966;93(3):400-402. doi:10.1001/archsurg.1966.01330030030006

THE FUNCTIONAL competence of allogenic lung grafts has been studied by many methods. These include differential bronchospirometry, occlusion of the contralateral pulmonary artery by a balloon catheter or by ligation, and contralateral pneumonectomy. In previously reported investigations1,2 untreated dogs were observed to survive from 3 to 96 hours after an allograft of one lung followed immediately by ligation of the opposite pulmonary artery. Buecherl and coworkers3,4 reported a mean survival of 1.3 days when the right pulmonary artery was ligated immediately after a left lung allograft. Faber et al5 performed ten such experiments in which the longest survivor lived for five days.

Zorzoli and co-workers6 ligated the opposite pulmonary artery some time after the autograft of one lung and one animal continued to prosper eight months later. Alican and Hardy7 suggested that delayed ligation of the contralateral pulmonary artery might be better tolerated than immediate

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