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September 1966

Biological Substrates and Cure Rates of Cyanoacrylate Tissue Adhesives

Author Affiliations

From the Division of Surgery, Walter Reed Army Institute of Research, and the US Army Medical Biomechanical Research Laboratory, Walter Reed Army Medical Center, Washington, DC.

Arch Surg. 1966;93(3):428-432. doi:10.1001/archsurg.1966.01330030058013

METHYL-2-CYANOACRYLATE is a monomer which rapidly polymerizes on contact with water or other surfaces which may serve as a source of anions. Because of its ability to adhere to living tissue surfaces and to form a strong bond when applied in a thin layer, methyl-2-cyanoacrylate has been used experimentally and clinically as a tissue adhesive and hemostasis inducing compound.1 Local tissue necrosis with this compound is very apparent, however, and work in progress at this center indicates that the higher N-alkyl substituted homologues of the 2-cyanoacrylates retain the necessary adhesive properties and exhibit significantly lower toxicity.2

While investigating the series of N-alkyl-2-cyanoacrylates in experimental surgical applications in dogs, differences in rates of polymerization were encountered which are contrary to what is known from in vitro water-based studies. It appears that the rate of polymer formation with the longer side chain compounds is considerably faster on

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