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October 1966

Canine Allografts (Homografts) of Islet Cell Tissue

Author Affiliations

From the Department of Surgery, Hahnemann Medical College, Philadelphia.

Arch Surg. 1966;93(4):598-605. doi:10.1001/archsurg.1966.01330040062011

THE SURGICAL treatment of diabetes, especially juvenile diabetes, remains an exciting hope. The problem of finding a suitable method for transplanting pancreatic tissue has been considered by several previous investigators. Gayet and Guillaumie1 were among the first to observe a reduction in blood sugar using a homotransplanted pancreas. Houssay and associates2 and later Bottin3 made similar observations. It appears that the first successful allografts with vascular reconstruction were produced by Dejode and Howard.4 These investigators used either the common hepatic artery or the celiac artery for the arterial supply to the pancreas. The gastroduodenal vein or a branch of the portal vein was used for venous drainage. A potentially significant advancement in the transplantation of islet cell tissue was made by Reemtsma et al.5 These investigators use a reduction in the blood sugar of a pancreatectomized dog as a criterion of islet cell function. They

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