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October 1966

Histopathology of Experimental Pancreatitis in the Dog: With Modification Resulting From Whole Body Hypothermia

Author Affiliations

From the departments of pathology and surgery, State University of New York at Buffalo and the Edward J. Meyer Memorial Hospital, Buffalo.

Arch Surg. 1966;93(4):606-613. doi:10.1001/archsurg.1966.01330040070012

EXPERIMENTAL pancreatitis in the dog has usually been produced by injection of bile or other substances into the pancreatic ducts with such force as to produce ductal rupture. Using several variations of this technique, Nabseth,1-3 Enquist,4 Bruck,5 and Kunze6 have reported on the production of experimental pancreatitis in the dog but with inconsistent results so far as the prevention of a fatal outcome by hypothermia. An experimental pancreatitis, felt by many to more closely approximate the pathogenesis of that seen in man, was described by McCutcheon and Race7 using the blind duodenal loop technique described earlier by Pfeffer.8 Using this method, which does not involve pancreatic duct trauma, we have been able to produce an experimental pancreatitis, the mortality of which can be substantially improved by whole body hypothermia (unpublished data). The purpose of this communication is to report the histopathology resulting from this

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