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November 1966

Experimental Heart Failure: Importance of Precapillary Coronary Arteriovenous Shunts

Author Affiliations

From the departments of surgery and pathology, Western Reserve University School of Medicine and Cleveland Metropolitan General Hospital, Cleveland. Dr. Haiderer is a Junior Research Fellow of the Heart Association of Northeastern Ohio, Inc.

Arch Surg. 1966;93(5):759-766. doi:10.1001/archsurg.1966.01330050063009

THE COMMON aims of the various methods1-3 of assisted circulation now under laboratory or clinical assessment are temporary relief of the heart from a greater or lesser portion of its mechanical work while improving the perfusion of the rest of the body. Proof that the heart has been helped by such intervention is not always easily achieved. The evaluation of myocardial oxygen consumption as a direct function of the difference between the oxygen content of aortic and coronary sinus blood is a classical method which has enjoyed wide application in the experimental and diagnostic cardiovascular laboratory.4,5 However, other investigators have noted that oxygenated blood appears in the coronary sinus under certain circumstances. In 1947, Eckenhoff and coworkers4 observed that in animals in "circulatory collapse" coronary venous blood contained more oxygen than the mixed venous blood collected in the right ventricle. Catchpole and associates6 demonstrated striking increase

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