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November 1966

Fibrillation in Empty and Loaded Ventricles: An Experimental Study of Coronary Artery Ligation During Partial and Complete Cardiac Bypass

Author Affiliations

From the Surgical Service, Veterans Administration Hospital, and the Department of Surgery, State University of New York at Buffalo School of Medicine, Buffalo.

Arch Surg. 1966;93(5):795-801. doi:10.1001/archsurg.1966.01330050099014

IN THE course of as yet unpublished experiments involving ligation of a major coronary artery in the supported, pacemade, beating, but empty canine heart, we observed that ventricular extrasystoles, tachyarrhythmias, and fibrillation were an exceptional occurrence. The increased tolerance of the heart to interruption of its blood supply under these circumstances had been recognized and often been alluded to by cardiac surgeons and physiologists but a systematic verification of the effect of ventricular decompression in regard to arrhythmias has not been made. Quantification of the incidence of ventricular fibrillation following coronary artery ligation with the left ventricle either loaded or empty is the subject of the first part of this report. The remainder of the data deals with some implications of the results of these studies for techniques of left ventricular bypass.

Methods and Materials  Eighteen mongrel dogs, weighing from 12 to 16.3 kg, were anesthetized with sodium pentobarbital (30

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