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January 1967

Growth of Brown-Pearce Carcinoma in the Presence of Bacteria

Author Affiliations

From the Department of Surgery, Louisiana State University School of Medicine, New Orleans.

Arch Surg. 1967;94(1):8-10. doi:10.1001/archsurg.1967.01330070010002

BACTERIA exert an inhibitory effect on the growth of tumors of the colon. Vink1 first demonstrated this experimentally in 1954. He reported that control of the bacterial flora of the colon by intestinal antisepsis increased the incidence of tumor growth at an anastomotic site in the colon. Cohn and Atik2 found an increase in growth of the Brown-Pearce carcinoma at the anastomotic site in rabbits when the intestinal flora was reduced and trauma increased. Christensen and Kjems3,4 demonstrated that rabbits with Brown-Pearce tumor growing in the testicle had a diminished incidence of metastases following massive streptococcal infection or therapy with lysates of streptococci. Miller and Ketcham5 showed a decrease in the implantation and growth of tumor cells in experimental, infected, operative wounds in mice and reported that an intimate contact between bacteria and tumor cells was necessary for inhibition of tumor growth, since infection at a