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February 1967

Nasopharyngeal Carcinomas in Children

Author Affiliations

Ann Arbor, Mich
From the Department of Pathology, University of Michigan, Ann Arbor.

Arch Surg. 1967;94(2):214-217. doi:10.1001/archsurg.1967.01330080052015

MALIGNANT neoplasms of the nasopharynx are uncommon in children. In Dargeon's review of 506 cases of childhood malignancies, only 27 were primary in the nasopharynx.1 In order of incidence, nasopharyngeal malignant neoplasms ranked behind neoplasms of bone, reticuloendothelial system, soft tissue, the eye and orbit, and the genitourinary tract.

Epithelial malignancies occurring during childhood are greatly outnumbered by neoplasms of other tissues. Together with the gliomas and neuroblastomas, carcinomas comprise an estimated 29% of all malignant neoplasms of childhood. Sarcomas, lymphomas, and the leukemias account for 71%.2

The nasopharynx, paradoxically, is one of the more common sites of origin of epithelial malignancy in children. Numerous single case reports attest to this observation.3-7 Clinicopathological evaluations of more than one or two patients treated at a single institution are exceptional. The largest single group of patients from one experience, prior to the present report, is the series of seven

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